format-version: 1.2
date: 30:4:2012 17:51
saved-by: jonathanbard
auto-generated-by: COBrA 1.2
typeref: anatomical_entity_ontology
default-namespace: anatomical_entity_ontology
remark: this version corrects the namespace and includes some flybase alt_IDs

[Term]
id: CL:0000099
name: interneuron
namespace: cell
def: "Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions." [GOC:tfm, MESH:A.08.663.358]
is_a: CL:0000540

[Term]
id: AEO:0000100
name: chitin-based structure
namespace: http\://www.xspan.org/obo.owl#
def: "Acellular anatomical structure whose predominant constituent is chitin." [AEO:JB]
alt_id: EHDAA2:0003100
is_a: CARO:0000040

[Term]
id: AEO:0000222
name: enclosed anatomical space
namespace: http\://www.xspan.org/obo.owl#
def: "An anatomical space with no opening to another space or to the exterior." [JB:AEO]
is_a: CARO:0000005

[Term]
id: CL:0000095
name: neuron associated cell
namespace: cell
is_a: CL:0002319

[Term]
id: AEO:0000221
name: open anatomical space
namespace: http\://www.xspan.org/obo.owl#
def: "An anatomical space with at least one opening to another space or the exterior." [JB:AEO]
is_a: CARO:0000005

[Term]
id: AEO:0000220
name: tooth
namespace: http\://www.xspan.org/obo.owl#
def: "Each of a set of hard\, bony enamel-coated structures in the jaws of most vertebrates\, used for biting and chewing." [JB:AEO]
alt_id: EHDAA2:0004605
is_a: CARO:0000055

[Term]
id: AEO:0000103
name: body
namespace: http\://www.xspan.org/obo.owl#
def: "The region of the organism associated with the visceral organs." [AEO:JB]
alt_id: EHDAA2:0003103
is_a: CARO:0000032

[Term]
id: AEO:0000109
name: tail
namespace: http\://www.xspan.org/obo.owl#
def: "An external caudal extension of the body." [AEO:JB]
alt_id: EHDAA2:0003109
is_a: AEO:0000193

[Term]
id: AEO:0000108
name: neck
namespace: http\://www.xspan.org/obo.owl#
def: "The region of the body connecting the head and the body." [AEO:JB]
alt_id: EHDAA2:0003108
is_a: CARO:0000032

[Term]
id: AEO:0000106
name: head
namespace: http\://www.xspan.org/obo.owl#
def: "The region of the body containing the brain and mouth." [AEO:JB]
alt_id: EHDAA2:0003106
is_a: CARO:0000032

[Term]
id: CARO:0000032
name: organism subdivision
namespace: http\://www.xspan.org/obo.owl#
def: "Anatomical structure which is a primary subdivision of whole organism. The mereological sum of these is the whole organism." [CARO:MAH]
alt_id: EHDAA2:0003032
alt_id: UBERON:0000475
is_a: CARO:0000003

[Term]
id: AEO:0000213
name: bone condensation
namespace: http\://www.xspan.org/obo.owl#
def: "A delimited region of osteoblasts representing the early stages of bone formation." [AEO:JB]
alt_id: EHDAA2:0003258
is_a: AEO:0000148
relationship: has_part CL:0000062

[Term]
id: AEO:0000212
name: sclerotome
namespace: http\://www.xspan.org/obo.owl#
def: "The mesenchymal derivative of a somite that will migrate to surround the neural tube and form vertebrae." [AEO:JB]
alt_id: EHDAA2:0003257
is_a: AEO:0001016
relationship: has_part CL:0000134
is_a: AEO:0000152

[Term]
id: CL:0000988
name: hematopoietic cell
namespace: cell
def: "A cell of a hematopoietic lineage." [GO_REF:0000031, GOC:add]
synonym: "haematopoietic cell" []
synonym: "haemopoietic cell" []
synonym: "hemopoietic cell" []
is_a: CL:0002371

[Term]
id: AEO:0000215
name: open cavity
namespace: http\://www.xspan.org/obo.owl#
def: "A volume that is mainly bounded but has an opening to another cavity or to the outside." [JB:AEO]
alt_id: EHDAA2:0003078
is_a: AEO:0000221

[Term]
id: AEO:0000214
name: dermomyotome
namespace: http\://www.xspan.org/obo.owl#
def: "The bilaminar epithelium formed from the myotome and dermatome." [AEO:JB]
alt_id: EHDAA2:0003259
relationship: has_part CL:0000075
is_a: CARO:0000069
is_a: AEO:0000132

[Term]
id: CL:0000081
name: blood cell
namespace: cell
def: "A cell found predominately in the blood." [GOC:add, GOC:tfm]
is_a: CL:0000988

[Term]
id: CARO:0000029
name: hermaphroditic organism
namespace: http\://www.xspan.org/obo.owl#
def: "Multi-cellular organism that can produce both male and female gametes." [CARO:MAH]
synonym: "dioecious organism" []
is_a: CARO:0000012

[Term]
id: AEO:0000211
name: non-connected developing functional system
namespace: http\://www.xspan.org/obo.owl#
def: "The sum of all the anlagen and primordia that will develop into a single functional system." [FBbt:DOS]
alt_id: FBbt:0004003
alt_id: HDAA2:0003256
is_a: CARO:0000041
is_a: AEO:0000125

[Term]
id: AEO:0000210
name: row
namespace: http\://www.xspan.org/obo.owl#
def: "Anatomical group whose component structures are arranged in a row." [DBft:DOS]
alt_id: FBbt:00100152
alt_id: HDAA2:0003255
is_a: CARO:0000054

[Term]
id: CARO:0000027
name: male organism
namespace: http\://www.xspan.org/obo.owl#
def: "Gonochoristic organism that can produce male gametes." [CARO:MAH]
is_a: CARO:0000048

[Term]
id: CARO:0000028
name: female organism
namespace: http\://www.xspan.org/obo.owl#
def: "Gonochoristic organism that can produce female gametes." [CARO:MAH]
is_a: CARO:0000048

[Term]
id: CL:0000080
name: circulating cell
namespace: cell
def: "A cell which moves among different tissues of the body\, via blood\, lymph\, or other medium." [GOC:add]
is_a: CL:0000144

[Term]
id: AEO:0000217
name: migrating developing tissue
namespace: http\://www.xspan.org/obo.owl#
def: "A simple coherent tissue or a localized population of similar cells that are actively migrating." [JB:AEO]
alt_id: EHDAA2:0004053
is_a: AEO:0000125

[Term]
id: CARO:0000021
name: simple organ
namespace: http\://www.xspan.org/obo.owl#
def: "Multi-tissue structure that is not part of a compound organ." [CARO:MAH]
alt_id: EHDAA2:0003190
is_a: CARO:0000055

[Term]
id: AEO:0000216
name: epithelial cord
namespace: http\://www.xspan.org/obo.owl#
def: "A cord of epithelial cells without a lumen and usually several cells thick." [JB:AEO]
alt_id: EHDAA2:0004052
is_a: CARO:0000066
relationship: has_part CL:0000079

[Term]
id: AEO:0000219
name: vascular plexus
namespace: http\://www.xspan.org/obo.owl#
def: "A network of interlinked veins." [JB:AEO]
alt_id: EHDAA2:0004112
relationship: has_part CL:0000071
is_a: AEO:0000118

[Term]
id: AEO:0000218
name: developing epithelial placode
namespace: http\://www.xspan.org/obo.owl#
def: "A domain of columnar epithelium in an embryo that represents the early stage of the development of the epithelial component of a new anatomical structure." [JB:AEO]
alt_id: EHDAA2:0003112
relationship: has_part CL:0000075
is_a: AEO:0001007

[Term]
id: CARO:0000024
name: compound organ
namespace: http\://www.xspan.org/obo.owl#
def: "Anatomical structure that has as its parts two or more multi-tissue structures of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona fide boundaries from other distinct anatomical structures of different types." [CARO:MAH]
alt_id: EHDAA2:0003024
is_a: CARO:0000003

[Term]
id: CL:0000079
name: stratified epithelial cell
namespace: cell
is_a: CL:0000066
is_a: CL:0002371

[Term]
id: AEO:0000127
name: apoptosing developing anatomical entity
namespace: http\://www.xspan.org/obo.owl#
def: "An embryonic anatomical structure undergoing apoptosis." [AEO:JB]
alt_id: EHDAA2:0003127
relationship: has_part CL:0000445
is_a: AEO:0000125

[Term]
id: AEO:0000126
name: larva
namespace: http\://www.xspan.org/obo.owl#
def: "A post-embryonic juvenile form which will undergo metamorphosis to become the adult." [AEO:JB]
alt_id: EHDAA2:0003126
is_a: CARO:0000012

[Term]
id: AEO:0000125
name: developing anatomical structure
namespace: http\://www.xspan.org/obo.owl#
def: "A structure whose morphology or state of differentiation will change during normal development." [AEO:JB]
alt_id: EHDAA2:0003125
alt_id: UBERON:0005423
is_a: CARO:0000003

[Term]
id: AEO:0000123
name: neural tissue
namespace: http\://www.xspan.org/obo.owl#
def: "Tissue composed predominantly of neurons." [AEO:JB]
alt_id: EHDAA2:0003123
is_a: CARO:0000043

[Term]
id: AEO:0000122
name: muscle tissue
namespace: http\://www.xspan.org/obo.owl#
def: "A tissue composed of myoblasts or muscle cells." [AEO:JB]
alt_id: EHDAA2:0003122
is_a: CARO:0000043

[Term]
id: CL:0000499
name: stromal cell
namespace: cell
def: "A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere." [GOC:tfm, MESH:A.11.329.830]
is_a: CL:0002320

[Term]
id: CARO:0000054
name: anatomical group
namespace: http\://www.xspan.org/obo.owl#
def: "Anatomical structure consisting of at least two non-overlapping organs\, multi-tissue aggregates or portion of tissues or cells of different types that does not constitute an organism\, organ\, multi-tissue aggregate\, or portion of tissue." [CARO:MAH]
alt_id: EHDAA2:0003054
alt_id: UBERON:0000480
is_a: CARO:0000003

[Term]
id: CARO:0000055
name: multi-tissue structure
namespace: http\://www.xspan.org/obo.owl#
def: "Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types." [CARO:MAH]
alt_id: EHDAA2:0003055
alt_id: UBERON:0000481
is_a: CARO:0000003

[Term]
id: CL:0002320
name: connective tissue cell
namespace: cell
def: "A cell of the supporting or framework tissue of the body\, arising chiefly from the embryonic mesoderm and including adipose tissue\, cartilage\, and bone." [GOC:tfm, ISBN:0618947256]
alt_id: CL:1000406
is_a: CL:0002371

[Term]
id: AEO:0000129
name: functioning and developing structure
namespace: http\://www.xspan.org/obo.owl#
def: "An embryonic entity that displays a physiological function but whose strucuture is not yet fully formed." [AEO:JB]
alt_id: EHDAA2:0003129
is_a: AEO:0000125

[Term]
id: CARO:0000050
name: protogynous hermaphroditic organism
namespace: http\://www.xspan.org/obo.owl#
def: "Sequential hermaphroditic organism that produces gametes first of the female sex\, and then later of the male sex." [CARO:MAH]
is_a: CARO:0000045

[Term]
id: CL:0002319
name: neural cell
namespace: cell
def: "A cell that is part of the nervous system." [GOC:tfm, ISBN:0618947256]
is_a: CL:0002371

[Term]
id: AEO:0000114
name: epithelial tube
namespace: http\://www.xspan.org/obo.owl#
def: "An epithelial structure capable of allowing fluid flow." [AEO:JB]
alt_id: EHDAA2:0003114
relationship: has_part CL:0000068
is_a: CARO:0000066

[Term]
id: AEO:0000115
name: epithelial sac
namespace: http\://www.xspan.org/obo.owl#
def: "An epithelial pouch with a single opening." [AEO:JB]
alt_id: EHDAA2:0003115
relationship: has_part CL:0000075
is_a: CARO:0000066

[Term]
id: AEO:0000111
name: mesothelium
namespace: http\://www.xspan.org/obo.owl#
def: "Epithelium derived from mesenchyme." [AEO:JB]
alt_id: EHDAA2:0003111
is_a: CARO:0000070

[Term]
id: CARO:0000043
name: simple tissue
namespace: http\://www.xspan.org/obo.owl#
def: "Anatomical structure\, that consists of similar cells and intercellular matrix\, aggregated according to genetically determined spatial relationships." [CARO:MAH]
alt_id: EHDAA2:0003043
alt_id: UBERON:0000479
synonym: "portion of tissue." []
is_a: CARO:0000003

[Term]
id: CARO:0000045
name: sequential hermaphroditic organism
namespace: http\://www.xspan.org/obo.owl#
def: "Hermaphroditic organism that produces gametes first of one sex\, and then later of the other sex." [CARO:MAH]
synonym: "consecutive hermaphroditic organism" []
is_a: CARO:0000029

[Term]
id: CARO:0000046
name: synchronous hermaphroditic organism
namespace: http\://www.xspan.org/obo.owl#
def: "Hermaphroditic organism that produces both male and female gametes at the same time." [CARO:MAH]
synonym: "serially hermaphroditic organism" []
is_a: CARO:0000029

[Term]
id: AEO:0000118
name: epithelial plexus
namespace: http\://www.xspan.org/obo.owl#
def: "A network of interlinking epithelial tubes." [AEO:JB]
alt_id: EHDAA2:0003118
relationship: has_part CL:0000068
is_a: AEO:0000114

[Term]
id: CARO:0000048
name: gonochoristic organism
namespace: http\://www.xspan.org/obo.owl#
def: "Multi-cellular organism that has male and female sexes." [CARO:MAH]
synonym: "monoecious organism" []
is_a: CARO:0000012

[Term]
id: AEO:0000117
name: arborising epithelial duct system
namespace: http\://www.xspan.org/obo.owl#
def: "A group of connected epithelial tubes with a single portal." [AEO:JB]
alt_id: EHDAA2:0003117
relationship: has_part CL:0000068
is_a: AEO:0000115

[Term]
id: CARO:0000049
name: protandrous hermaphroditic organism
namespace: http\://www.xspan.org/obo.owl#
def: "Sequential hermaphroditic organism that produces gametes first of the male sex\, and then later of the female sex." [CARO:MAH]
is_a: CARO:0000045

[Term]
id: CARO:0000040
name: acellular anatomical structure
namespace: http\://www.xspan.org/obo.owl#
def: "Anatomical structure that consists of cell parts and cell substances and together does not constitute a cell or a tissue." [CARO:MAH]
alt_id: EHDAA2:0003040
alt_id: UBERON:0000476
is_a: CARO:0000003

[Term]
id: CARO:0000042
name: extraembryonic structure
namespace: http\://www.xspan.org/obo.owl#
def: "Anatomical structure that is contiguous with the embryo and is comprised of portions of tissue or cells that will not contribute to the embryo." [CARO:MAH]
alt_id: EHDAA2:0003042
alt_id: UBERON:0000478
is_a: CARO:0000003

[Term]
id: CARO:0000041
name: anatomical cluster
namespace: http\://www.xspan.org/obo.owl#
def: "Anatomical group that has its parts adjacent to one another. Anatomical structure\, which has as its parts a heterogeneous collection of organs\, organ parts\, cells or body part subdivisions that are adjacent to\, or continuous with one another; does not constitute an organ\, organ system or organ system subdivision\, or body part or body part subdivision." [CARO:MAH]
alt_id: EHDAA2:0003041
alt_id: UBERON:0000477
is_a: CARO:0000054

[Term]
id: CARO:0000077
name: epithelial cell
namespace: http\://www.xspan.org/obo.owl#
def: "Cell which has as its part a cytoskeleton that allows for tight cell to cell contact and which has apical-basal cell polarity." [CARO:MAH, CL:0000066]
is_a: CARO:0000013

[Term]
id: AEO:0000144
name: striated muscle sphincter
namespace: http\://www.xspan.org/obo.owl#
def: "A ring of striated muscle cells whose contraction closes the opening of the ring." [AEO:JB]
alt_id: EHDAA2:0003144
relationship: has_part CL:0000737
is_a: AEO:0000140

[Term]
id: AEO:0000145
name: mesenchymal tissue
namespace: http\://www.xspan.org/obo.owl#
def: "A group of not-yet-terminally-differentiatied cells that can pack in three dimensions." [AEO:JB]
alt_id: EHDAA2:0003145
is_a: CARO:0000043

[Term]
id: AEO:0000142
name: cardiac muscle tissue
namespace: http\://www.xspan.org/obo.owl#
def: "A tissue composed of cardiac muscle cells." [AEO:JB]
alt_id: EHDAA2:0003142
relationship: has_part CL:0000746
is_a: AEO:0000122

[Term]
id: AEO:0000143
name: smooth muscle sphincter
namespace: http\://www.xspan.org/obo.owl#
def: "A ring of smooth muscle cells whose contraction closes the opening of the ring." [AEO:JB]
alt_id: EHDAA2:0003143
relationship: has_part CL:0000192
is_a: AEO:0000141

[Term]
id: CL:0002242
name: nucleate cell
namespace: cell
def: "A cell containing at least one nucleus." [GOC:tfm]
is_a: CL:0000224

[Term]
id: AEO:0000148
name: developing mesenchymal condensation
namespace: http\://www.xspan.org/obo.owl#
def: "A delimited region of dense mesenchyme within looser mesenchyme." [AEO:JB]
alt_id: EHDAA2:0003148
is_a: AEO:0000146
is_a: AEO:0001016
relationship: has_part CL:0000335

[Term]
id: AEO:0000149
name: pre-muscle condensation
namespace: http\://www.xspan.org/obo.owl#
def: "A delimited region of dense mesenchyme within looser mesenchyme whose cells are committed to become myoblasts." [AEO:JB]
alt_id: EHDAA2:0003149
is_a: AEO:0000148
relationship: has_part CL:0000680

[Term]
id: AEO:0000146
name: dense mesenchyme tissue
namespace: http\://www.xspan.org/obo.owl#
def: "Mesenchyme with little extracellular matrix." [AEO:JB]
alt_id: EHDAA2:0003146
relationship: has_part CL:0000057
is_a: AEO:0000145

[Term]
id: AEO:0000147
name: cartilagenous condensation
namespace: http\://www.xspan.org/obo.owl#
def: "Cell condensation that is an aggregation of mesenchymal cells that are committed to differentiate into chondroblasts and chondrocytes." [AEO:JB, GO:curator, VAO:0000092]
alt_id: EHDAA2:0003147
relationship: has_part CL:0000058
is_a: AEO:0000148

[Term]
id: CL:0000737
name: striated muscle cell
namespace: cell
def: "Muscle cell which has as its direct parts myofilaments organized into sarcomeres." [GOC:tfm, ISBN:0721662544]
is_a: CL:0000187

[Term]
id: AEO:0000152
name: migrating mesenchyme population
namespace: http\://www.xspan.org/obo.owl#
def: "Mesenchymal cells that are migrating." [AEO:JB]
alt_id: EHDAA2:0003152
relationship: has_part CL:0000134
is_a: AEO:0000145

[Term]
id: AEO:0000151
name: loose mesenchyme tissue
namespace: http\://www.xspan.org/obo.owl#
def: "Mesenchyme whose cells are embedded in obvious amounts fo extracellular matrix." [AEO:JB]
alt_id: EHDAA2:0003151
relationship: has_part CL:0000327
relationship: has_part CL:0000057
is_a: AEO:0000145

[Term]
id: AEO:0000150
name: pre-cartilage condensation
namespace: http\://www.xspan.org/obo.owl#
def: "A delimited region of dense mesenchyme within looser mesenchyme whose cells are committed to become chondroblasts." [AEO:JB]
alt_id: EHDAA2:0003150
is_a: AEO:0000148
relationship: has_part CL:0000335

[Term]
id: CARO:0000074
name: solid compound organ
namespace: http\://www.xspan.org/obo.owl#
def: "Compound organ that does not contain macroscopic anatomical spaces." [CARO:MAH]
alt_id: EHDAA2:0003074
is_a: CARO:0000024

[Term]
id: CARO:0000072
name: cavitated compound organ
namespace: http\://www.xspan.org/obo.owl#
def: "Compound organ that contains one or more macroscopic anatomical spaces." [CARO:MAH]
alt_id: EHDAA2:0003072
is_a: CARO:0000024

[Term]
id: CARO:0000073
name: unilaminar epithelium
namespace: http\://www.xspan.org/obo.owl#
def: "Epithelium that consists of a single layer of epithelial cells." [CARO:MAH]
alt_id: EHDAA2:0003073
is_a: CARO:0000066

[Term]
id: CARO:0000070
name: simple squamous epithelium
namespace: http\://www.xspan.org/obo.owl#
def: "Unilaminar epithelium that consists of a single layer of squamous cells." [CARO:MAH]
alt_id: EHDAA2:0003070
relationship: has_part CL:0000076
is_a: CARO:0000073

[Term]
id: CARO:0000071
name: atypical epithelium
namespace: http\://www.xspan.org/obo.owl#
def: "Epithelium that consists of epithelial cells not arranged in one ore more layers." [CARO:MAH]
alt_id: EHDAA2:0003071
relationship: has_part CL:0000066
is_a: CARO:0000066

[Term]
id: CL:0000211
name: electrically active cell
namespace: cell
def: "A cell whose function is determined by the generation or the reception of an electric signal." [FB:ma]
is_a: CL:0000144

[Term]
id: AEO:0000139
name: nerve fiber tract
namespace: http\://www.xspan.org/obo.owl#
def: "A fasciculated bundle of neuron projections\, largely or completely lacking synapses." [CARO:0001001, GO:0043005]
alt_id: EHDAA2:0003139
synonym: "neuron projection bundle" [GO:0043005]
is_a: AEO:0001011

[Term]
id: CARO:0000069
name: multilaminar epithelium
namespace: http\://www.xspan.org/obo.owl#
def: "Epithelium that consists of more than one layer of epithelial cells." [CARO:MAH]
alt_id: EHDAA2:0003069
is_a: CARO:0000066

[Term]
id: CARO:0000066
name: epithelium
namespace: http\://www.xspan.org/obo.owl#
def: "Portion of tissue\, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina." [CARO:MAH]
alt_id: EHDAA2:0003066
is_a: CARO:0000043

[Term]
id: CARO:0000065
name: basal lamina
namespace: http\://www.xspan.org/obo.owl#
def: "Acellular anatomical structure that consists of a thin sheet of fibrous proteins that underlie and support the cells of an epithelium. It separates the cells of an epithelium from any underlying tissue." [CARO:MAH]
alt_id: EHDAA2:0003065
is_a: CARO:0000040
relationship: part_of CARO:0000066

[Term]
id: CARO:0000068
name: columnar epithelium
namespace: http\://www.xspan.org/obo.owl#
def: "Unilaminar epithelium that consists of a single layer of columnar cells." [CARO:MAH]
alt_id: EHDAA2:0003068
is_a: CARO:0000073

[Term]
id: CARO:0000067
name: simple cuboidal epithelium
namespace: http\://www.xspan.org/obo.owl#
def: "Unilaminar epithelium that consists of a single layer of cuboidal cells." [CARO:MAH]
alt_id: EHDAA2:0003067
relationship: has_part CL:0000075
is_a: CARO:0000073

[Term]
id: AEO:0000131
name: developing structure with stem cells
namespace: http\://www.xspan.org/obo.owl#
def: "Embronic structure that contains stem cellsr that may contribute to its future development or maintenance or to its future development or maintenance of another tissue." [AEO:JB]
alt_id: EHDAA2:0003131
is_a: AEO:0000125
relationship: has_part CL:0000034

[Term]
id: AEO:0000132
name: transitional anatomical structure
namespace: http\://www.xspan.org/obo.owl#
def: "An embryonic anatomical entity that will turn into one or more other anatomical entities\, perhaps with other anatomical entities\, later in development." [AEO:JB]
alt_id: EHDAA2:0003132
is_a: AEO:0000125

[Term]
id: AEO:0000135
name: ganglion
namespace: http\://www.xspan.org/obo.owl#
def: "A group of neurons\, usually outside the CNS\, which relay neuronal signals." [AEO:JB]
alt_id: EHDAA2:0003135
is_a: AEO:0000123

[Term]
id: AEO:0000136
name: neuronal nucleus
namespace: http\://www.xspan.org/obo.owl#
def: "A localised domain of predominantly neuronal tissue in the central nervous system." [AEO:JB]
alt_id: EHDAA2:0003136
relationship: has_part CL:0000127
relationship: has_part CL:0000129
is_a: AEO:0001012
relationship: has_part CL:0000128

[Term]
id: CL:0000393
name: electrically responsive cell
namespace: cell
def: "A cell whose function is determined by its response to an electric signal." [FB:ma]
is_a: CL:0000211

[Term]
id: AEO:0000137
name: nerve
namespace: http\://www.xspan.org/obo.owl#
def: "A group of neurons that provides a nervous supply." [AEO:JB]
alt_id: EHDAA2:0003137
is_a: AEO:0000123

[Term]
id: AEO:0000138
name: nerve plexus
namespace: http\://www.xspan.org/obo.owl#
def: "A complex of interconnecting nerves." [AEO:JB]
alt_id: EHDAA2:0003138
relationship: has_part CL:0000526
relationship: has_part CL:0000527
is_a: AEO:0000123

[Term]
id: CL:0000746
name: cardiac muscle cell
namespace: cell
def: "A myocyte located in the heart. The contractile fiber resembles those of skeletal muscle but are only one third as large in diameter\, are richer in sarcoplasm\, and contain centrally located instead of peripheral nuclei." [GOC:tfm, ISBN:0323052908]
synonym: "cardiac myocyte" []
synonym: "cardiocyte" []
synonym: "cardiomyocyte" []
synonym: "heart muscle cell" []
is_a: CL:0000737

[Term]
id: AEO:0000141
name: smooth muscle tissue
namespace: http\://www.xspan.org/obo.owl#
def: "A tissue composed of smooth muscle cells." [AEO:JB]
alt_id: EHDAA2:0003141
is_a: AEO:0000122
relationship: has_part CL:0000192

[Term]
id: AEO:0000140
name: striated muscle tissue
namespace: http\://www.xspan.org/obo.owl#
def: "A tissue composed of striated muscle cells." [AEO:JB]
alt_id: EHDAA2:0003140
is_a: AEO:0000122
relationship: has_part CL:0000737

[Term]
id: CL:0000228
name: multinucleate cell
namespace: cell
def: "A cell with more than one nucleus." [FB:ma]
synonym: "syncitium" []
synonym: "syncytial cell" []
synonym: "syncytium" []
is_a: CL:0002242

[Term]
id: CARO:0000062
name: cell space
namespace: http\://www.xspan.org/obo.owl#
def: "Anatomical space that is part of a cell." [CARO:mah]
is_a: CARO:0000005

[Term]
id: CARO:0000063
name: asexual organism
namespace: http\://www.xspan.org/obo.owl#
def: "Multi-cellular organism that does not produce gametes." [CARO:MAH]
is_a: CARO:0000012

[Term]
id: CARO:0000064
name: single cell organism
namespace: http\://www.xspan.org/obo.owl#
def: "Cell that is an individual member of a species." [CARO:MAH]
is_a: CARO:0000013

[Term]
id: CL:0000243
name: glial cell (sensu Vertebrata)
namespace: cell
def: "A non-neuronal cell of the nervous system. They not only provide physical support\, but also respond to injury\, regulate the ionic and chemical composition of the extracellular milieu. Form the myelin insulation of nervous pathways\, guide neuronal migration during development\, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems\, voltage-dependent and transmitter-gated ion channels\, and can release transmitters\, but their role in signaling (as in many other functions) is unclear." [MESH:A.08.637]
is_a: CL:0000125

[Term]
id: CL:0000224
name: cell by nuclear number
namespace: cell
def: "A classification of cells by the number of their nuclei." [FB:ma, GOC:tfm]
is_a: CL:0000012

[Term]
id: AEO:0000168
name: skeletal system
namespace: http\://www.xspan.org/obo.owl#
def: "The rigid support system for the body." [AEO:JB, VAO:0000027]
alt_id: EHDAA2:0003168
is_a: CARO:0000011

[Term]
id: AEO:0001021
name: stem cell population
namespace: http\://www.xspan.org/obo.owl#
def: "A group of cells capable of regenerating themselves and also of producing one or more populations of differentiated cells." [AEO:JB]
is_a: CARO:0000043

[Term]
id: AEO:0000169
name: embryo
namespace: http\://www.xspan.org/obo.owl#
def: "That part of the conceptus that will form the organism." [AEO:JB]
alt_id: EHDAA2:0003169
alt_id: UBERON:0000922
alt_id: ZFA:0001105
relationship: part_of AEO:0000194
is_a: CARO:0000012

[Term]
id: AEO:0001020
name: reproductive cell population
namespace: http\://www.xspan.org/obo.owl#
def: "A population of cells that are predominantly immature or mature germ cells." [AEO:JB]
is_a: CARO:0000043
relationship: has_part  CL:0000039

[Term]
id: AEO:000020
name: fat tissue
namespace: http\://www.xspan.org/obo.owl#
def: "Tissue that is predominantly made of fat cells." [AEO:JB]
alt_id: EHDAA2:0003120
relationship: has_part CL:0000136
is_a: CARO:0000043

[Term]
id: AEO:0000174
name: gender-specific anatomical structure
namespace: http\://www.xspan.org/obo.owl#
def: "A part of the body present only in a specific gender." [AEO:JB]
alt_id: EHDAA2:0003174
is_a: CARO:0000003

[Term]
id: AEO:0001015
name: somite
namespace: http\://www.xspan.org/obo.owl#
def: "An epithelial ball that forms from paraxial mesoderm." [JB:AEO]
is_a: AEO:0000119f

[Term]
id: AEO:0001016
name: developing mesenchymal structure
namespace: http\://www.xspan.org/obo.owl#
def: "A mesenchyme-derived anatomical entity undergoing a transtion to become another structure." [AEO:JB]
is_a: AEO:0000125

[Term]
id: AEO:0000173
name: surface sense organ
namespace: http\://www.xspan.org/obo.owl#
def: "Multicellular anatomical structure with largely bona fide boundary that extends outwards from or is part of the organism surface and transduces some sensory stimulus to the nervous system." [AEO:JB]
alt_id: EHDAA2:0003173
relationship: part_of AEO:0000154
is_a: AEO:0000094

[Term]
id: AEO:0001017
name: dermatome
namespace: http\://www.xspan.org/obo.owl#
def: "A transitional population of migrating mesenchymal cells that derive from somites and that will become dermal cells." [AEO:JB]
is_a: AEO:0001016
is_a: AEO:0000217

[Term]
id: AEO:0000172
name: limb
namespace: http\://www.xspan.org/obo.owl#
def: "Appendage of an animal used for locomotion or grasping." [AEO:JB]
alt_id: EHDAA2:0003172
is_a: AEO:0000193

[Term]
id: AEO:0000171
name: primordium
namespace: http\://www.xspan.org/obo.owl#
def: "Primordia are populations of contiguous cells that are morphologically distinct and already correspond in extent to a later organ/tissue." [AEO:JB]
alt_id: EHDAA2:0003171
is_a: AEO:0000125

[Term]
id: AEO:0001018
name: myotome
namespace: http\://www.xspan.org/obo.owl#
def: "A transitional population of migrating mesenchymal cells that derive from somites and that will become muscle cells." [AEO:JB]
is_a: AEO:0001016
is_a: AEO:0000217

[Term]
id: AEO:0000170
name: anlage
namespace: http\://www.xspan.org/obo.owl#
def: "Anlagen are populations of contiguous cells\, typically arranged in one plane\, that are morphologically indistinct\, but that already correspond in extent to a later organ/tissue." [AEO:JB]
alt_id: EHDAA2:0003170
is_a: AEO:0000125

[Term]
id: AEO:0001011
name: neuronal white matter
namespace: http\://www.xspan.org/obo.owl#
def: "Neuronal tissue composed predominantly of axons." [AEO:JB]
alt_id: EHDAA2:0004657
is_a: AEO:0000123

[Term]
id: AEO:0001012
name: neuronal grey matter
namespace: http\://www.xspan.org/obo.owl#
def: "A neuronal tissue composed predominantly of nerve bodies and neuronal support cells." [AEO:JB]
alt_id: EHDAA2:0004658
is_a: AEO:0000123

[Term]
id: AEO:0001013
name: neuronal column
namespace: http\://www.xspan.org/obo.owl#
def: "An extended columnar domain of predominantly neuronal tissue in the central nervous system." [AEO:JB]
alt_id: EHDAA2:0004659
relationship: has_part CL:0000127
relationship: has_part CL:0000129
is_a: AEO:0001012
relationship: has_part CL:0000128

[Term]
id: AEO:0001014
name: differentiating neuronal condensation
namespace: http\://www.xspan.org/obo.owl#
def: "A compact group of cells differentiating to become a ganglion or a neuronal nucleus." [AEO:JB]
alt_id: EHDAA2:0004660
is_a: AEO:0000125
relationship: has_part CL:0000031
relationship: has_part CL:0000468

[Term]
id: AEO:0001019
name: developing germ cell population
namespace: http\://www.xspan.org/obo.owl#
def: "A germ cell population that has not undergone meiosis." [AEO\:JB]
is_a: AEO:0000125

[Term]
id: CL:0002372
name: myotube
namespace: cell
def: "A myotube is a multinucleated cells that is formed when proliferating myoblasts exit the cell cycle\, differentiate and fuse." [GOC:tfm, ISBN:0323052908]
alt_id: CL:0000369
synonym: "myotubule" []
synonym: "single cell sarcomere" []
synonym: "skeletal muscle fiber" []
is_a: CL:0000228
is_a: CL:0000188
is_a: CL:0000737

[Term]
id: CL:0002371
name: somatic cell
namespace: cell
def: "A cell of an organism that does not pass on its genetic material to the organism's offspring (i.e. a non-germ line cell)." [GOC:tfm, ISBN:0721662544]
is_a: CL:0000144

[Term]
id: AEO:0000013
name: single-cell tissue
namespace: http\://www.xspan.org/obo.owl#
def: "Anatomical structure composed of a single cell." [CARO:MAH]
alt_id: EHDAA2:0003013
is_a: CARO:0000043

[Term]
id: AEO:0001010
name: differentiating neuroepithelium
namespace: http\://www.xspan.org/obo.owl#
def: "A neuroepithelium some of whose cells are undergoing terminal differentiation to become neuronal cells." [AEO:JB]
alt_id: EHDAA2:0004656
relationship: has_part CL:0000031
is_a: AEO:0001008
relationship: has_part CL:0000468

[Term]
id: AEO:0000153
name: mesenchymal tissue with stem cells
namespace: http\://www.xspan.org/obo.owl#
def: "Multi-tissue mesenchymal structure one of whose parts contains stem cells that can replace other parts." [AEO:JB]
alt_id: EHDAA2:0003153
is_a: AEO:0000187

[Term]
id: AEO:0000154
name: organism surfacef
namespace: http\://www.xspan.org/obo.owl#
def: "The collection of structures that form the exxtenal covering of the organism." [AEO:JB]
alt_id: EHDAA2:0003154
is_a: CARO:0000032

[Term]
id: AEO:0000161
name: groove
namespace: http\://www.xspan.org/obo.owl#
def: "A furrow or an incomplete tube." [AEO:JB]
alt_id: EHDAA2:0003161
alt_id: UBERON:0006846
alt_id: ZFA:0001690
is_a: AEO:0000192

[Term]
id: AEO:0001006
name: excreta
namespace: http\://www.xspan.org/obo.owl#
def: "Excreta are bodily fluids consisting of waste matter\, such as sweat or feces\, discharged from the body." [JB:AEO]
alt_id: UBERON:0000174
is_a: CARO:0000004

[Term]
id: CL:0000107
name: autonomic neuron
namespace: cell
def: "A neruon whose cell body is within an autonomic ganglion." [GOC:tfm]
is_a: CL:0000540

[Term]
id: AEO:0001007
name: developing epithelium
namespace: http\://www.xspan.org/obo.owl#
def: "An epithelium within an embryo or larva that is undergoing a major developmental change." [AEO:JB]
alt_id: EHDAA2:0004653
is_a: AEO:0000125
is_a: CARO:0000066

[Term]
id: AEO:0001004
name: fin
namespace: http\://www.xspan.org/obo.owl#
def: "A flattened appendage on a marine animal." [JB:AEO, VAO:0000099]
is_a: AEO:0000193

[Term]
id: AEO:0000162
name: ridge
namespace: http\://www.xspan.org/obo.owl#
def: "A raised strip of tissue." [AEO:JB]
alt_id: EHDAA2:0003162
is_a: AEO:0000192

[Term]
id: AEO:0001005
name: secretion
namespace: http\://www.xspan.org/obo.owl#
def: "A non-cellular substance released by a cell\, gland or tissue." [JB:AEO]
alt_id: UBERON:0000456
is_a: CARO:0000004

[Term]
id: AEO:0001002
name: capillary bed
namespace: http\://www.xspan.org/obo.owl#
def: "A localized group of blood capillaries." [JB:AEO]
is_a: AEO:0000118

[Term]
id: AEO:0001003
name: acellular extracellular matrix
namespace: http\://www.xspan.org/obo.owl#
def: "An acellular structure typically composed of collagen\, glycoproteins and glycosaminoglycans." [JB:AEO]
is_a: CARO:0000040

[Term]
id: AEO:0001000
name: sensory ganglion
namespace: http\://www.xspan.org/obo.owl#
def: "A ganglion containing sensory neurons." [JB:AEO]
is_a: AEO:0000135
relationship: has_part CL:0000243
relationship: has_part CL:0002573
relationship: has_part CL:0000101

[Term]
id: CL:0000101
name: sensory neuron
namespace: cell
def: "Any neuron having a sensory function; an afferent neuron conveying sensory impulses." [ISBN:0721662544]
is_a: CL:0000526

[Term]
id: AEO:0001001
name: autonomic ganglion
namespace: http\://www.xspan.org/obo.owl#
def: "A ganglion that is part of the autonomic nervous system." [JB:AEO]
relationship: has_part CL:0000526
relationship: has_part CL:0000107
relationship: has_part CL:0000527
is_a: AEO:0000135
relationship: has_part CL:0000243
relationship: has_part CL:0002573

[Term]
id: AEO:0001008
name: neuroepithelium
namespace: http\://www.xspan.org/obo.owl#
def: "An embryonic or larval epithelium that is committed to form part of the nervous system." [AEO:JB]
alt_id: EHDAA2:0004654
relationship: has_part CL:0000075
is_a: AEO:0001007

[Term]
id: AEO:0001009
name: proliferating neuroepithelium
namespace: http\://www.xspan.org/obo.owl#
def: "An epithelium that is undergoing proliferation to provide large numbers of neuronal cells." [AEO:JB]
alt_id: EHDAA2:0004655
relationship: has_part CL:0000075
is_a: AEO:0001008

[Term]
id: AEO:0000094
name: sense organ
namespace: http\://www.xspan.org/obo.owl#
def: "Multicellular anatomical structure with largely bona fide boundary that transduces some sensory stimulus to the nervous system." [AEO:JB]
alt_id: EHDAA2:0003094
alt_id: FBbt:00005155
is_a: CARO:0000024

[Term]
id: AEO:0000095
name: fluid-based anatomical entity
namespace: http\://www.xspan.org/obo.owl#
def: "Fluid anatomical entity containing cells." [AEO:JB]
alt_id: EHDAA2:0003095
is_a: CARO:0000055

[Term]
id: CL:0000144
name: cell by function
namespace: cell
def: "A classification of cells by their primary end goal or behavior." [FB:ma]
is_a: CL:0000012

[Term]
id: AEO:0000096
name: gland
namespace: http\://www.xspan.org/obo.owl#
def: "A multi-tissue structure that produces a secretion for use elsewhere in the body." [AEO:JB]
alt_id: EHDAA2:0003096
is_a: CARO:0000055

[Term]
id: AEO:0000097
name: ducted gland
namespace: http\://www.xspan.org/obo.owl#
def: "A gland that releases its secretion through a duct." [AEO:JB]
alt_id: EHDAA2:0003097
synonym: "exocrine gland." []
is_a: AEO:0000096

[Term]
id: CL:0000327
name: extracellular matrix secreting cell
namespace: cell
is_a: CL:0000151
is_a: CL:0000499

[Term]
id: AEO:0000090
name: ligament
namespace: http\://www.xspan.org/obo.owl#
def: "A strap of predominantly extracellular matrix connecting two bones." [AEO:JB]
alt_id: EHDAA2:0003090
relationship: has_part CL:0000327
relationship: has_part CL:0000057
is_a: AEO:0000081
relationship: part_of AEO:0000168

[Term]
id: AEO:0000091
name: tendon
namespace: http\://www.xspan.org/obo.owl#
def: "A strap of predominantly extracellular matrix connecting a muscle to a bone." [AEO:JB]
alt_id: EHDAA2:0003091
relationship: has_part CL:0000327
relationship: has_part CL:0000057
is_a: AEO:0000081
relationship: part_of AEO:0000168

[Term]
id: AEO:0000092
name: aponeurosis
namespace: http\://www.xspan.org/obo.owl#
def: "A sheet of extracellular matrix." [AEO:JB]
alt_id: EHDAA2:0003092
relationship: has_part CL:0002320
relationship: has_part CL:0000327
is_a: AEO:0000081

[Term]
id: AEO:0000093
name: non-connected functional system
namespace: http\://www.xspan.org/obo.owl#
def: "An anatomical group whose component structures share a common function." [AEO:JB]
alt_id: EHDAA2:0003093
alt_id: FBbt:00007278
is_a: CARO:0000041

[Term]
id: CL:0000670
name: primordial germ cell
namespace: cell
def: "A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells." [GOC:tfm, PMID:1381289]
synonym: "Gonocyte" []
synonym: "Primitive germ cell" []
is_a: CL:0000039

[Term]
id: CL:0000468
name: neuroglioblast
namespace: cell
is_a: CL:0000055

[Term]
id: AEO:0000192
name: anatomical surface feature
namespace: http\://www.xspan.org/obo.owl#
def: "Non-material anatomical entity of two dimensions\, that is demarcated by anatomical lines or points on the external or internal surfaces of anatomical structures." [CARO:MAH]
alt_id: EHDAA2:0003010
synonym: "anatomical surface." []
is_a: CARO:0000010

[Term]
id: AEO:0000193
name: appendage
namespace: http\://www.xspan.org/obo.owl#
def: "Organ or organ part that is attached to the body of an organism. For example a limb\[GO\, modified\]. An appendage is an external body part\, or natural prolongation\, that protrudes from an organism's body\, such as a vertebrate's limbs." [CARO:MAH]
alt_id: EHDAA2:0003193
alt_id: UBERON:0000026
is_a: CARO:0000032

[Term]
id: AEO:0000194
name: conceptus
namespace: http\://www.xspan.org/obo.owl#
def: "All the products of the fertilized egg." [AEO:JB]
alt_id: EHDAA2:0003205
is_a: CARO:0000012

[Term]
id: AEO:0000195
name: extraembryonic component
namespace: http\://www.xspan.org/obo.owl#
def: "The part of the conceptus that may be lost before birth or will be discarded at birth\, or when the embryo becomes an independent organism." [AEO:JB]
relationship: part_of AEO:0000194
is_a: CARO:0000055

[Term]
id: AEO:0000196
name: larval anatomical structure
namespace: http\://www.xspan.org/obo.owl#
def: "An anatomical structure present in the larval form of an animal." [AEO:JB]
alt_id: HDAA2:0003126
is_a: AEO:0000125
relationship: part_of AEO:0000126

[Term]
id: CL:0000003
name: cell in vivo
namespace: cell
is_a: CL:0000000

[Term]
id: CL:0000667
name: collagen secreting cell
namespace: cell
def: "An extracellular matrix secreting cell that secretes collagen." [GOC:tfm]
is_a: CL:0000327

[Term]
id: AEO:0000187
name: multi-tissue structure with stem cells
namespace: http\://www.xspan.org/obo.owl#
def: "Multi-tissue structure one of whose parts contains stem cells that can replace other parts." [AEO:JB]
alt_id: EHDAA2:0003187
is_a: CARO:0000055

[Term]
id: AEO:0000186
name: body cavity
namespace: http\://www.xspan.org/obo.owl#
def: "The cavity within the body that contains the visceral organs." [AEO:JB]
alt_id: EHDAA2:0003186
alt_id: UBERON:0002323
is_a: CARO:0000005

[Term]
id: CL:0000526
name: afferent neuron
namespace: cell
def: "A neuron which conveys sensory information centrally from the periphery." [GOC:tfm, MESH:A.08.663.650]
synonym: "input neuron" []
is_a: CL:0000540

[Term]
id: AEO:0000189
name: epithelial tissue with stem cells
namespace: http\://www.xspan.org/obo.owl#
def: "Multi-tissue epithelial structure one of whose parts contains stem cells that can replace other parts." [AEO:JB]
alt_id: EHDAA2:0003189
is_a: AEO:0000187

[Term]
id: CL:0000527
name: efferent neuron
namespace: cell
def: "A neuron which sends impulses peripherally to activate muscles or secretory cells." [MESH:A.08.663.655]
synonym: "output neuron" []
is_a: CL:0000540

[Term]
id: AEO:0000188
name: acellular fluid anatomical entity
namespace: http\://www.xspan.org/obo.owl#
def: "An acellular fluid portion of organism substance that is produced by the organism for some non-waste purpose." [AEO:JB]
alt_id: EHDAA2:0003188
is_a: CARO:0000040

[Term]
id: CL:0000151
name: secretory cell
namespace: cell
def: "A cell that specializes in controlled release of one or more substances." [GOC:tfm, ISBN:0721662544]
is_a: CL:0000144

[Term]
id: CL:0000525
name: syncytiotrophoblast cell
namespace: cell
def: "A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo. It It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy." [GOC:tfm, ISBN:0323052908]
synonym: "plasmidotrophoblast" []
synonym: "syncytial trophoblast" []
synonym: "syntrophoblast" []
is_a: CL:0000228

[Term]
id: AEO:0000087
name: cartilage
namespace: http\://www.xspan.org/obo.owl#
def: "Dense connective tissue made primarily of type II collagen." [AEO:JB, VAO:0000040]
alt_id: EHDAA2:0003087
is_a: AEO:0000081
relationship: part_of AEO:0000168

[Term]
id: CL:0000136
name: fat cell
namespace: cell
def: "A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides." [MESH:A.11.329.114]
alt_id: CL:0000450
synonym: "adipocyte" []
synonym: "adipose cell" []
is_a: CL:0002320

[Term]
id: AEO:0000085
name: membrane bone
namespace: http\://www.xspan.org/obo.owl#
def: "Bone that forms directly from mesenchyme." [AEO:JB, VAO:0000023]
alt_id: EHDAA2:0003085
is_a: AEO:0000082
relationship: has_part CL:0000062
relationship: part_of AEO:0000168

[Term]
id: AEO:0000086
name: sesamoid bone
namespace: http\://www.xspan.org/obo.owl#
def: "An endochondral bone that forms within tendenous or ligamentous matrix." [AEO:JB, VAO:0000137]
alt_id: EHDAA2:0003086
relationship: has_part CL:0000058
relationship: has_part CL:0000138
is_a: AEO:0000083
relationship: part_of AEO:0000168

[Term]
id: CL:0000134
name: mesenchymal cell
namespace: cell
def: "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. This cell type is CD73-positive\, CD90-positive\, CD105-positive\, CD45-negative\, CD34-negative\, and MHCII-negative. They may further differentiate into osteoblasts\, adipocytes\, myocytes\, neurons\, or chondroblasts in vitro.  Originally described as residing in the bone marrow\, this cell type is now known to reside in many\, if not all\, adult organs." [FB:ma, GOC:dsd, http://en.wikipedia.org/wiki/Mesenchymal_stem_cell, http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells, PMCID:PMC2613570, PMID:10102814j, PMID:16923606, PMID:_17986482, PMID:_19960544]
alt_id: CL:0002452
synonym: "BMSC" []
synonym: "bone marrow stromal cells" []
synonym: "CFU-F" []
synonym: "colony-forming unit-fibroblast" []
synonym: "marrow stromal cells" [PMID:11378515]
synonym: "mesenchymal precursor cell" []
synonym: "mesenchymal progenitor cells" [MESH:D044982]
synonym: "mesenchymal stem cell" []
synonym: "mesenchymal stromal cell" []
synonym: "mesenchymal stromal cells" []
synonym: "MSC" [PMID:11378515]
synonym: "Stem Cells\, Mesenchymal" [MESH:D044982]
is_a: CL:0000063

[Term]
id: AEO:0000083
name: endochondral bone
namespace: http\://www.xspan.org/obo.owl#
def: "Bone that is preformed in cartilage." [AEO:JB, VAO:0000145]
alt_id: EHDAA2:0003083
is_a: AEO:0000082
relationship: has_part CL:0000058
relationship: has_part CL:0000138
relationship: has_part CL:0000062
relationship: part_of AEO:0000168

[Term]
id: AEO:0000081
name: matrix-based tissue
namespace: http\://www.xspan.org/obo.owl#
def: "A tissue whose predominant feature is extracellular matrix which may or may not be highly hydrated or calcified." [AEO:JB]
alt_id: EHDAA2:0003081
is_a: CARO:0000043

[Term]
id: AEO:0000082
name: bone
namespace: http\://www.xspan.org/obo.owl#
def: "Ossified structure that is predominantly extracellular matrix and forms part of the support system of the body." [AEO:JB]
alt_id: EHDAA2:0003082
is_a: CARO:0000055

[Term]
id: CL:0000138
name: chondrocyte
namespace: cell
def: "Polymorphic cell that form cartilage." [MESH:A.11.329.171]
synonym: "cartilage cell" []
is_a: CL:0000667

[Term]
id: AEO:0000080
name: foramen
namespace: http\://www.xspan.org/obo.owl#
def: "A hole in a tissue." [AEO:JB]
alt_id: EHDAA2:0003080
is_a: AEO:0000192

[Term]
id: AEO:0000180
name: non-joint-associated cartilage
namespace: http\://www.xspan.org/obo.owl#
def: "Cartilage that may provide the template for an endochondral bone or that may be a disinct entity in the skeleton." [AEO:JB]
alt_id: EHDAA2:0003180
is_a: AEO:0000087
relationship: has_part CL:0000058
relationship: has_part CL:0000138
relationship: part_of AEO:0000168

[Term]
id: AEO:0000181
name: synovial membrane
namespace: http\://www.xspan.org/obo.owl#
def: "The epithelial membrane between bone ends that forms the lateral borders of the synovial cavity and secretes synovial fluid." [AEO:JB]
alt_id: EHDAA2:0003181
is_a: CARO:0000069
relationship: has_part CL:0000079
relationship: part_of AEO:0000183

[Term]
id: AEO:0000185
name: exoskeletal tissue
namespace: http\://www.xspan.org/obo.owl#
def: "A component of the exoskeleton." [AEO:JB]
alt_id: EHDAA2:0003185
relationship: has_part CL:0000658
is_a: AEO:0000081
relationship: part_of AEO:0000168

[Term]
id: AEO:0000183
name: synovial joint
namespace: http\://www.xspan.org/obo.owl#
def: "A joint connecting two or more bones with cartilage at the bone ends and a synovial membrane that secretes synovial fluid conecting the bones and sealing the synovial cavity." [AEO:JB]
alt_id: EHDAA2:0003183
is_a: CARO:0000055
relationship: part_of AEO:0000168

[Term]
id: AEO:0000178
name: fibrous joint
namespace: http\://www.xspan.org/obo.owl#
def: "A flexible joint between two bones that is made of unossified connective tissue." [AEO:JB]
alt_id: EHDAA2:0003178
relationship: has_part CL:0002320
is_a: AEO:0000081
relationship: part_of AEO:0000168

[Term]
id: AEO:0000177
name: hermaphrodite anatomical structure
namespace: http\://www.xspan.org/obo.owl#
def: "A part of the body present only in hermaphrodites." [AEO:JB]
alt_id: EHDAA2:0003177
is_a: AEO:0000174

[Term]
id: CL:0000000
name: cell
namespace: cell
def: "Anatomical structure that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." [CARO:mah]

[Term]
id: AEO:0000176
name: female anatomical structure
namespace: http\://www.xspan.org/obo.owl#
def: "A part of the body present only in females." [AEO:JB]
alt_id: EHDAA2:0003176
is_a: AEO:0000174

[Term]
id: AEO:0000175
name: male anatomical structure
namespace: http\://www.xspan.org/obo.owl#
def: "A part of the body present only in males." [AEO:JB]
alt_id: EHDAA2:0003175
is_a: AEO:0000174

[Term]
id: AEO:0000179
name: joint-associated cartilage
namespace: http\://www.xspan.org/obo.owl#
def: "The articular cartilage covering of the region of bone within a synoval joint." [AEO:JB]
alt_id: EHDAA2:0003179
is_a: AEO:0000087
relationship: has_part CL:0000058
relationship: has_part CL:0000138
relationship: part_of AEO:0000083
relationship: part_of AEO:0000183

[Term]
id: CL:0000658
name: cuticle secreting cell
namespace: cell
def: "An epithelial cell that secretes cuticle." [GOC:tfm]
is_a: CL:0000066
is_a: CL:0000327

[Term]
id: AEO:0000079
name: lumen of epithelial sac
namespace: http\://www.xspan.org/obo.owl#
def: "A small cavity bounded by an epithelium." [AEO:JB]
alt_id: EHDAA2:0003079
synonym: "cavity of vesicle" []
is_a: AEO:0000222

[Term]
id: AEO:0000078
name: lumen of tube
namespace: http\://www.xspan.org/obo.owl#
def: "The inner space within a tube." [AEO:JB]
alt_id: EHDAA2:0003078
alt_id: UBERON:0005082
synonym: "tube lumen" []
is_a: AEO:0000221

[Term]
id: CL:0000127
name: astrocyte
namespace: cell
def: "A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes\, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment\, and 'reactive astrocytes' (along with microglia) respond to injury." [GOC:_tfm, GOC:dsd, MESH:A.08.637.200, MESH:D001253, PMID:11746784, PMID:12162730, PMID:12898703, PMID:20942978]
synonym: "astrocytic glia" []
is_a: CL:0000128

[Term]
id: CL:0000126
name: macroglial cell
namespace: cell
def: "A neuroglial cell of ectodermal origin\, i.e.\, the astrocytes and oligodendrocytes considered together." [GOC:tfm, ISBN:0721662544]
synonym: "Macrogliocyte" []
is_a: CL:0000243

[Term]
id: CL:0000129
name: microglial cell
namespace: cell
def: "A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive\, F4/80-positive\, and CD68-positive." [GOC:add, GOC:dsd, GOC:tfm, ISBN:0721601464, MESH:D017628, PMID:11517395, PMID:12430718, PMID:14561199, PMID:14612429, PMID:16177057, PMID:19461673, PMID:2089275]
synonym: "brain macrophage" []
synonym: "brain-resident macrophage" []
synonym: "hortega cells" [http://www.copewithcytokines.de/]
synonym: "MF.microglia.CNS" []
synonym: "microglia" []
synonym: "microgliocyte" [http://www.copewithcytokines.de/]
is_a: CL:0000243

[Term]
id: CL:0000128
name: oligodendrocyte
namespace: cell
def: "A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system." [MESH:A.08.637.600]
synonym: "oligodendroglia" []
is_a: CL:0000126

[Term]
id: CL:0000125
name: glial cell
namespace: cell
def: "A non-neuronal cell of the nervous system. They not only provide physical support\, but also respond to injury\, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development\, and exchange metabolites with neurons." [MESH:A.08.637]
synonym: "neuroglia" []
synonym: "neuroglial cell" []
is_a: CL:0000095

[Term]
id: CL:0000444
name: obliquely striated muscle cell
namespace: cell
is_a: CL:0000737

[Term]
id: CL:0000029
name: neuron neural crest derived
namespace: cell
is_a: CL:0000540

[Term]
id: CL:0000445
name: apoptosis fated cell
namespace: cell
is_a: CL:0000144

[Term]
id: CL:0000031
name: neuroblast
namespace: cell
is_a: CL:0000055

[Term]
id: CL:0000540
name: neuron
namespace: cell
def: "The basic cellular unit of nervous tissue. Each neuron consists of a body\, an axon\, and dendrites. Their purpose is to receive\, conduct\, and transmit impulses in the nervous system." [MESH:A.08.663, MESH:D009474]
synonym: "nerve cell" []
is_a: CL:0000393

[Term]
id: CL:0000335
name: mesenchyme condensation cell
namespace: cell
def: "A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors." [GOC:tfm, PMID:5025404]
is_a: CL:0000134

[Term]
id: CL:0000015
name: male germ cell
namespace: cell
def: "A germline cell that contributes to the development of the oocyte by transferring cytoplasm directly to oocyte." [GOC:tfm, PMID:15848391]
synonym: "nurse cell" []
is_a: CL:0000586

[Term]
id: CL:0000012
name: cell by class
namespace: cell
is_a: CL:0000003

[Term]
id: CL:0000021
name: female germ cell
namespace: cell
def: "Female germ cell is a germ cell that supports female gamete production." [GOC:tfm, PMID:11023867, PMID:20454446]
is_a: CL:0000586

[Term]
id: AEO:0000199
name: mucous membrane
namespace: http\://www.xspan.org/obo.owl#
def: "A membranous structure with more than one cell type\, one or more of which secretes mucus\, that lines body passages which communicate with the exterior." [AEO:JB]
alt_id: EHDAA2:0003234
synonym: "mucosa" []
is_a: CARO:0000055

[Term]
id: AEO:0000198
name: antenna
namespace: http\://www.xspan.org/obo.owl#
def: "A head-associated surface sense organ." [CARO:MAH]
relationship: part_of AEO:0000106
relationship: part_of AEO:0000154
is_a: AEO:0000173

[Term]
id: CL:0000188
name: skeletal muscle cell
namespace: cell
def: "A somatic cell located in skeletal muscle." [GOC:tfm]
is_a: CL:0000187

[Term]
id: CL:0000192
name: smooth muscle cell
namespace: cell
def: "A non-striated\, elongated\, spindle-shaped cell found lining the digestive tract\, uterus\, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast)." [MESH:A.11.620.520, MESH:D032389, PMID:9315361]
alt_id: CL:0000191
synonym: "myocytes\, smooth muscle" [MESH:D032389]
synonym: "non-striated muscle cell" []
synonym: "SMCs" [PMID:9315361]
synonym: "smooth muscle fiber" []
is_a: CL:0000187

[Term]
id: CL:0000196
name: flight muscle cell
namespace: cell
is_a: CL:0000187

[Term]
id: CL:0000055
name: non-terminally differentiated cell
namespace: cell
def: "A precursor cell with a limited number of potential fates." [SANBI:mhl]
synonym: "blast cell" []
is_a: CL:0000012

[Term]
id: CL:0002573
name: Schwann cell
namespace: cell
def: "A glial cell that ensheathes axons of neuron in the peripheral nervous system and are necessary for their maintainance and function." [GOC:tfm]
is_a: CL:0000243

[Term]
id: CL:0000414
name: cell by ploidy
namespace: cell
def: "A classification of cells by the number of haploid genome equivalents of their nucleus or nuclei." [FB:ma, GOC:tfm]
is_a: CL:0000012

[Term]
id: CL:0000039
name: germ line cell
namespace: cell
def: "A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring." [GOC:tfm, ISBN:0721662544]
comment: Originally this term had some plant germ line cell children
is_a: CL:0000144

[Term]
id: CL:0000034
name: stem cell
namespace: cell
def: "A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:tfm, MESH:A.11.872]
is_a: CL:0000144

[Term]
id: CL:0000187
name: muscle cell
namespace: cell
def: "A mature contractile cell\, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." [MESH:A.11.620]
synonym: "myocyte" []
is_a: CL:0000393
is_a: CL:0002371

[Term]
id: CL:0000068
name: duct epithelial cell
namespace: cell
is_a: CL:0000066
is_a: CL:0002371

[Term]
id: CARO:0000011
name: anatomical system
namespace: http\://www.xspan.org/obo.owl#
def: "Anatomical group that is has as its parts distinct anatomical structures interconnected by anatomical structures at a lower level of granularity." [CARO:MAH]
alt_id: EHDAA2:0003011
is_a: CARO:0000054

[Term]
id: CARO:0000010
name: anatomical surface
namespace: http\://www.xspan.org/obo.owl#
def: "Non-material anatomical entity of two dimensions\, that is demarcated by anatomical lines or points on the external or internal surfaces of anatomical structures." [CARO:MAH]
alt_id: EHDAA2:0003192
alt_id: UBERON:0000015
is_a: CARO:0000007

[Term]
id: CARO:0000013
name: cell
namespace: http\://www.xspan.org/obo.owl#
def: "Anatomical structure that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." [CARO:MAH]
is_a: CARO:0000003

[Term]
id: CARO:0000012
name: multi-cellular organism
namespace: http\://www.xspan.org/obo.owl#
def: "Anatomical structure that is an individual member of a species and consists of more than one cell." [JB:DEF]
alt_id: EHDAA2:0003191
alt_id: UBERON:0000468
is_a: CARO:0000003

[Term]
id: CL:0000586
name: germ cell
namespace: cell
def: "The reproductive cell in multicellular organisms." [MESH:A.05.360.490]
is_a: CL:0000039

[Term]
id: CARO:0000014
name: cell component
namespace: http\://www.xspan.org/obo.owl#
def: "Anatomical structure that is a direct part of the cell." [CARO:MAH]
is_a: CARO:0000003
relationship: part_of CARO:0000013

[Term]
id: CL:0000071
name: blood vessel endothelial cell
namespace: cell
def: "An endothelial cell that lines the vasculature." [GOC:tfm]
synonym: "Cuboidal endothelial cell of vascular tree" []
is_a: CL:0000076

[Term]
id: CARO:0000019
name: compound organ component
namespace: http\://www.xspan.org/obo.owl#
def: "Multi-tissue structure that is part of a compound organ." [CARO:MAH]
alt_id: EHDAA2:0003019
relationship: part_of CARO:0000024
is_a: CARO:0000055

[Term]
id: CL:0000075
name: columnar/cuboidal epithelial cell
namespace: cell
is_a: CL:0000066
is_a: CL:0002371

[Term]
id: CL:0000076
name: squamous epithelial cell
namespace: cell
is_a: CL:0000066

[Term]
id: CL:0000058
name: chondroblast
namespace: cell
def: "An immature cartilage-producing cell found in growing cartilage." [GOC:tfm, ISBN:0618947256]
synonym: "chrondoplast" []
is_a: CL:0000667
is_a: CL:0002320
is_a: CL:0000055

[Term]
id: CL:0000057
name: fibroblast
namespace: cell
def: "A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped." [http://63.198.234.228/OpenFMA/Fibroblast.html, ISBN:0517223651, MESH:A.11.329.228]
is_a: CL:0002320

[Term]
id: AEO:0000119f
name: epithelial vesicle
namespace: http\://www.xspan.org/obo.owl#
def: "A closed epithelium with a lumen." [AEO:JB]
alt_id: EHDAA2:0003119
relationship: has_part CL:0000075
is_a: CARO:0000066

[Term]
id: CL:0000680
name: muscle precursor cell
namespace: cell
is_a: CL:0000055
is_a: CL:0002371

[Term]
id: CL:0000165
name: neuroendocrine cell
namespace: cell
def: "An endocrine cell that has the specialized function to produce and secrete hormones in response to neuronal signals." [MESH:A.06.688]
synonym: "neurosecretory cell" []
is_a: CL:0000393

[Term]
id: AEO:0000209
name: vein
namespace: http\://www.xspan.org/obo.owl#
def: "An epithelial tube that transports blood towards the heart." [AEO:JB]
alt_id: EHDAA2:0003254
is_a: AEO:0000207
relationship: has_part CL:0000071

[Term]
id: CARO:0000000
name: anatomical entity
namespace: http\://www.xspan.org/obo.owl#
def: "Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species." [CARO:MAH]
alt_id: EHDAA2:0003000
alt_id: UBERON:0001062

[Term]
id: AEO:0000098
name: ductless gland
namespace: http\://www.xspan.org/obo.owl#
def: "A gland that releases its secretion directly into the bloodstream\, or equivalent for an invertebrate." [AEO:JB]
alt_id: EHDAA2:0003098
synonym: "endocrine gland." [AEO:JB]
is_a: AEO:0000096

[Term]
id: AEO:0000099
name: keratin-based structure
namespace: http\://www.xspan.org/obo.owl#
def: "Acellular anatomical structure whose predominant constituent is keratin." [AEO:JB]
alt_id: EHDAA2:0003099
is_a: CARO:0000040

[Term]
id: CARO:0000006
name: material anatomical entity
namespace: http\://www.xspan.org/obo.owl#
def: "Anatomical entity that has mass." [CARO:MAH]
alt_id: EHDAA2:0003006
alt_id: UBERON:0000465
is_a: CARO:0000000

[Term]
id: AEO:0000205
name: protuberance
namespace: http\://www.xspan.org/obo.owl#
def: "A roughly circular bulge in a surface." [AEO:JB]
alt_id: EHDAA2:0003250
is_a: AEO:0000192

[Term]
id: CARO:0000005
name: anatomical space
namespace: http\://www.xspan.org/obo.owl#
def: "Non-material anatomical entity of three dimensions\, that is generated by morphogenetic or other physiologic processes; is surrounded by one or more anatomical structures; contains one or more organism substances or anatomical structures." [CARO:MAH]
alt_id: EHDAA2:0003005
alt_id: UBERON:0000464
is_a: CARO:0000007

[Term]
id: AEO:0000206
name: migrating epithelium
namespace: http\://www.xspan.org/obo.owl#
def: "An epithelium that extends its surface area by peripheral movement." [AEO:JB]
alt_id: EHDAA2:0003251
relationship: has_part CL:0000066
is_a: CARO:0000066

[Term]
id: AEO:0000207
name: blood vessel
namespace: http\://www.xspan.org/obo.owl#
def: "An epithelial tube that transports blood." [AEO:JB]
alt_id: EHDAA2:0003252
relationship: has_part CL:0000071
is_a: AEO:0000114

[Term]
id: CARO:0000004
name: non-tissue substance
namespace: http\://www.xspan.org/obo.owl#
def: "Material anatomical entity in a gaseous\, liquid\, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body." [CARO:MAH]
alt_id: EHDAA2:0003004
alt_id: UBERON:0000463
synonym: "portion of organism substance" []
is_a: CARO:0000006

[Term]
id: CARO:0000003
name: anatomical structure
namespace: http\://www.xspan.org/obo.owl#
def: "Material anatomical entity that has inherent 3D shape and is generated by coordinated expression of the organism's own genome." [CARO:MAH]
alt_id: EHDAA2:0003003
alt_id: UBERON:0000061
is_a: CARO:0000006

[Term]
id: AEO:0000208
name: artery
namespace: http\://www.xspan.org/obo.owl#
def: "An epithelial tube that transports blood away from the heart." [AEO:JB]
alt_id: EHDAA2:0003253
is_a: AEO:0000207
relationship: has_part CL:0000071

[Term]
id: CL:0000062
name: osteoblast
namespace: cell
def: "A bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone." [MESH:A.11.329.629]
is_a: CL:0002320
is_a: CL:0000055

[Term]
id: AEO:0000201
name: afferent nerve
namespace: http\://www.xspan.org/obo.owl#
def: "A group of neurons that provides a nervous response from a tissue." [AEO:JB]
alt_id: EHDAA2:0003200
relationship: has_part CL:0000526
is_a: AEO:0000137

[Term]
id: CARO:0000009
name: anatomical point
namespace: http\://www.xspan.org/obo.owl#
def: "Non-material anatomical entity of zero dimension\, which forms a boundary of an anatomical line or surface." [CARO:MAH]
alt_id: EHDAA2:0003009
is_a: CARO:0000007

[Term]
id: AEO:0000202
name: efferent nerve
namespace: http\://www.xspan.org/obo.owl#
def: "A group of neurons that provides a nervous signal to a tissue." [AEO:JB]
alt_id: EHDAA2:0003231
relationship: has_part CL:0000527
is_a: AEO:0000137

[Term]
id: CARO:0000008
name: anatomical line
namespace: http\://www.xspan.org/obo.owl#
def: "Non-material anatomical entity of one dimension\, which forms a boundary of an anatomical surface or is a modulation of an anatomical surface." [CARO:MAH]
alt_id: EHDAA2:0003008
is_a: CARO:0000007

[Term]
id: AEO:0000203
name: syncytium
namespace: http\://www.xspan.org/obo.owl#
def: "An anatomical entity consisting of a single or a few multinucleated structures." [AEO.:JB]
alt_id: HDAA2:0003248
relationship: has_part CL:0000228
is_a: CARO:0000043

[Term]
id: AEO:0000204
name: pit
namespace: http\://www.xspan.org/obo.owl#
def: "An roughly circular indentation in a surface." [AEO:JB]
alt_id: EHDAA2:003249
is_a: AEO:0000192

[Term]
id: CARO:0000007
name: immaterial anatomical entity
namespace: http\://www.xspan.org/obo.owl#
def: "Anatomical entity that has no mass." [CARO:MAH]
alt_id: EHDAA2:0003007
alt_id: UBERON:0000466
is_a: CARO:0000000

[Term]
id: CL:0000066
name: epithelial cell
namespace: cell
def: "A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina." [FB:ma, GOC:tfm, MESH:A.11.436]
synonym: "Epitheliocyte" []
is_a: CL:0000063

[Term]
id: CL:0000063
name: cell by histology
namespace: cell
def: "A classification of cells by their microscopic appearance." [FB:ma, GOC:tfm]
is_a: CL:0000012

[Term]
id: AEO:0000200
name: regenerating anatomical structure
namespace: http\://www.xspan.org/obo.owl#
def: "An anatomical structure that\, as part of its normal physiology\, undergoes regeneration. Examples include endometrium and antlers." [AEO:JB]
alt_id: EHDAA2:0003233
is_a: CARO:0000003

[Typedef]
id: has_part
name: has_part

[Typedef]
id: descends
name: descends

[Typedef]
id: develops_from
name: develops_from

[Typedef]
id: subEventOf
name: subEventOf

[Typedef]
id: part_of
name: part_of

[Typedef]
id: startStage
name: startStage

[Typedef]
id: endStage
name: endStage

[Typedef]
id: isReferenceForMapping
name: isReferenceForMapping

[Typedef]
id: derives_from
name: derives_from

[Typedef]
id: type
name: type

[Typedef]
id: hasMapping
name: hasMapping